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TELMISTRUM NEBI 40-5 Telmisartan 40 mg & Nebivolol 5 mg TELMISTRUM NEBI 40-5 is a therapeutic approach for managing hypertension, offering complementary mechanisms of action that target different physiological pathways involved in blood pressure regulation. TELMISTRUM NEBI 40-5 can be particularly beneficial for patients requiring more than one medication to control their blood pressure, or for those who have specific cardiovascular risk factors or comorbidities. Understanding the roles and benefits of each medication helps to appreciate why they might be used together. Telmisartan Class: Angiotensin II Receptor Blocker (ARB) Mechanism of Action: Telmisartan blocks the action of angiotensin II, a potent vasoconstrictor, by selectively inhibiting the binding to the angiotensin II type 1 (AT1) receptors found in many tissues, such as vascular smooth muscle and the adrenal gland. This action leads to vasodilation, reduced secretion of aldosterone, decreased sodium retention, and ultimately, a decrease in blood pressure. Benefits: Telmisartan is known for its cardiovascular and renal protective effects, making it a favored choice for patients with hypertension and an increased risk of cardiovascular disease or chronic kidney disease. Nebivolol Class: Beta-Blocker, specifically a third-generation beta-blocker Mechanism of Action: Nebivolol is unique among beta-blockers because it combines selective β1-adrenergic receptor blockade with a nitric oxide (NO)-potentiating effect. This dual action leads to a decrease in heart rate and myocardial contractility (reducing cardiac output) and vasodilation (attributed to its NO-potentiating effect), respectively. The result is effective lowering of blood pressure with potential benefits in terms of endothelial function and vascular stiffness. Benefits: Due to its vasodilatory effects, Nebivolol tends to have fewer negative metabolic effects compared to traditional beta-blockers, such as less impact on lipid and glucose metabolism. It is also less likely to cause fatigue and sexual dysfunction, common side effects associated with older beta-blockers. TELMISTRUM NEBI 40-5 addresses blood pressure control from multiple angles: arterial resistance (Telmisartan) and cardiac output (Nebivolol), along with vascular endothelial function improvement (Nebivolol). This multi-faceted approach can be more effective for patients whose hypertension is not adequately controlled by monotherapy. Enhanced Cardiovascular Protection: Both medications offer cardiovascular protective benefits beyond their blood pressure-lowering effects, which may be particularly advantageous for patients with existing cardiovascular disease or at high risk of such conditions. Improved Side Effect Profile: Nebivolol's unique action may mitigate some of the common side effects associated with beta-blockers, such as bradycardia and fatigue, while Telmisartan is generally well-tolerated with a low risk of cough (a common side effect with ACE inhibitors). For further information please contact: info@sterispharma.com / contact@sterispharma.com call/whatsapp: 8209542042, 8955945010,7877551268, 6377716668, order now: https://www.sterisonline.com/product/telmistrum-nebi-40-5-134254
